What i can say is that a classical "blog" website with those configuration options enabled should perform well but if you have a "big" website (lot of contents, ezfind solr indexation, complex layouts) then extra settings must be applied depending on the performance problem.
To resume i'd need more information on the site setup if basic optimization isn't solving the problem.
first, you have to make sure that most caches are enabled. If it's the case, then you should make sure that your pages are correctly optimized. The usual way of doing this in eZ Publish is too use the cache-block template function to put some parts of the page in cache to decrease the number of SQL queries needed to generate a page. This function has to be used in the pagelayout.tpl or the templates included in it because by default, there's no cache strategy for those templates. You can see the number of SQL queries in debug output table. it's commonly admitted that 10 SQL queries or less to generate a page already in cache (ie in a second hit) is a good result.