About INI caches, from 4.1 you have a special setting in config.php :
define( 'EZP_INI_FILEMTIME_CHECK', false );
If you set this constant to false (highly recommended), you will have performace improvements but you'll have to clear INI cache each time to make a modification in some INI file. Besides, clear-all-caches doesn't seem to clear INI cache (maybe an issue), so you have to clear-ini manually ;).
About policies, I don't really know... What do you want to do exactly ?
As this is for development setup, do not enable the setting from Jérôme unless your found of clearing cache :) Additionally there are settings for disabling role cache witch you should search for in site.ini, and if you use ezjscore it has a setting for disabling cache as well (but it will disable caching automatically if it is not set and DevelopmentMode is enabled).