Could be good to know what is your real goal here.
I mean, articles need to change completely or just some parts (maybe blocks or something) of them?
I see your situation as articles having things in common, like 'latest content added' or things like that... is that the case?
Then you can think in refactoring your pagelayout.tpl and move there the parts that need to change, usign cache-block for that. If you already have your pagelayout build and doesn't want to change it, you can also think in doing a override for pagelayout and only those articles...
But note i'm saying this without knowing your real goal, so probably this couldn't be the best option.
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