<i>No</i>. The setup module should prevent you from setting up eZ Publish normally if safe mode is enabled. eZ Publish requires full access to your web server environment.
I for one will be glad when safe mode is removed from php with php6, <i>http://ez.no/developer/forum/general/article_php_6_changes</i>
Cheers, <i>//kracker
La Coka Nostra - That's Coke http://www.youtube.com/watch?v=K67JkUGY_sU</i>