If you just fill the center collumns, you will have just one collumn.
If you want a more complexe solution you need to create your class BiographiePage and to overide the /node/view/full.tpl template with a class filter on your class. To create your class go in setup/classes and to overide go in design/templates. Help you with the frontpage example.
An over solution, if you want to add many biographie easily in a frontpage. You will create a class Biographie, overide /content/view/full.tpl, Then to add a biographie you have to insert a new Biographie in your frontpage and, in the edit, click on the "insert object" button and select your instense.
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